George Lopez’s multi-faceted career encompasses television, film, standup comedy and late-night television. For two seasons, Lopez hosted Lopez Tonight, a late-night television talk show on TBS, which represented Lopez's return to series television after co-creating, writing, producing and starring in Warner Bros. Television's groundbreaking hit sitcom George Lopez, which ran for six seasons on ABC. George Lopez remains a hit with viewers in syndication on both broadcast stations and cable's Nick at Nite, ranking as one of the top-rated shows on the network and among the top five comedies and top 20 weekly programs in syndication.
On March 8, 2007, it was announced that George Lopez would join the Nick at Nite lineup. It first aired on Nick at Nite on September 10, 2007. On May 15, 2007, ABC announced that the series would be cancelled after its sixth season. The show last aired on ABC September 7, 2007. The show also entered syndication in the fall of 2007. Never a big Nielsen hit in prime-time, the show became a surprise success in syndication.
In 2006, Lopez received a star on the Hollywood Walk of Fame. In addition, Time magazine named him one of the 25 Most Influential Hispanics in America, and the Harris Poll named him one of the Top Ten Favorite Television Personalities.
On March 28, 2009, it was announced that Lopez would be hosting his own late night talk show on TBS. Lopez hosted a late-night talk show entitled Lopez Tonight on TBS Monday through Thursday at midnight Eastern Time. The show debuted in November 2009. In November 2010, the show moved back to midnight ET to accommodate a new show with former Tonight Show host Conan O'Brien. Lopez supported and even advocated for the move, making it different from the 2010 Tonight Show conflict that saw O'Brien depart NBC after a proposal to push Tonight back 30 minutes for Jay Leno to return to the 11:35 p.m. slot. On August 10, 2011 Lopez received a cancellation notice from TBS. The network decided not to renew Lopez Tonight for a third season.
On April 18, 2013, it was announced George Lopez would be starring in his own sitcom on FX called Saint George, which premiered on March 6, 2014. Saint George was produced under Debmar-Mercury and Lionsgate Television's syndication model, which states that if a show hits certain ratings thresholds in its first 10-episode run, it triggers an additional 90-episode order. Failing to do so, Saint George was canceled on June 25, 2014, after one season.
In August, 2015, TV Land announced a straight-to-series order for Lopez, a semi-autobiographical single-camera sitcom, which debuted on March 30, 2016.
George was invited to be a guest judge on America's Got Talent in 2016. He was allowed to use his golden buzzer once, which made an act go straight to the live shows. He used his on the dance group Malevo.